Chemical denaturation, a well-established technique, provides reliable thermodynamic values for protein stability. Avia Biosystems’ Model 2304 Automated Protein Denaturation System completely automates protein stability determinations using chemical denaturation. The system facilitates the formulation of biologics in a safe and stable form using intrinsic or extrinsic fluorescence to monitor the conformation changes associated with protein unfolding, and automatically generates complete protein stability curves. Up to 96 different formulations, process conditions or individual protein constructs can be evaluated for relative stability, and an individual stability curve generated for each. Sample preparation, data collection, data analysis and stability report-generation are all automated. Avia Biosystems
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