Cause of an inherited form of epilepsy discovered

Montreal, QC – Researchers at McGill University have discovered the cause of an inherited form of epilepsy. The disease, known as double-cortex syndrome, primarily affects females and arises from mutations on a gene located on the X chromosome. Using an advanced microscope, Drs. Susanne Bechstedt and Gary Brouhard of the Department of Biology, found how these mutations cause a malformation of the human brain. The results of their study are published in the journal Developmental Cell.

When the brain develops in the uterus, new brain cells are born deep within the brain, near the center. These newborn brain cells then crawl out of the so-called “niche” where they were born and migrate outward to the edges of the brain. This outermost layer of the brain is known as the cerebral cortex and is the seat of all higher-level thinking and cognition.

In girls with a mutation on their X chromosome, the outward migration of brain cells unfortunately fails. Instead of making it all the way to the edges of the brain, some of the brain cells pile up on top of one another and form a secondary or “double-cortex.” The activity of these abnormally placed brain cells gives rise to seizures and also, in some cases, mental retardation. Drs. Bechstedt and Brouhard were able to purify the product of the mutated gene, a protein known as doublecortin, and to watch the protein in action.

This discovery has implications for treatments for a range of conditions, from other forms of epilepsy to spinal cord injuries. Understanding how brain cells construct their skeletons will open avenues for doctors to target the brain cell skeleton to extend and re-grow when needed.

This research was funded by the Canadian Institutes of Health Research.

The Developmental Cell article is available here:
http://www.cell.com/developmental-cell/abstract/S1534-5807(12)00233-X