Epigenetics is a fast-growing research area with wide applications, including disease mechanism profiling and personalized medicine strategies. ChIP is crucial to epigenetic research.
Porvair Sciences, in conjunction with researchers at SwanseaUniversityin the UK have written a new technical article entitled ‘Chromatrap 96: a new solid-state platform for high-throughput Chromatin Immunoprecipitation (ChIP)’. Published recently in Nature Methods (11, 2014) the article provides an introduction to Chromatrap 96 – a high-throughput ChIP analysis platform – and demonstrates how it is able to profile up to 96 transcription factors and epigenetic modifications simultaneously in less than one day. The authors – Amy L Beynon, Lesley J Parkes, Matthew L Turner, Steve Knight, Steve Conlan, Lewis Francis & Ben Stocks – show how the solid-state platform enables sensitive, selective and reproducible target amplification with excellent signal-to-noise ratios, even from samples as small as 0.1 µg.
Further, the authors show the compatibility of the platform with automated handling allows for simultaneous investigation of parallel epigenetic landscapes, offering unprecedented ChIP assay flexibility and speed. Porvair
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