The LCMS-8040 triple quadrupole mass spectrometer combines improved ion optics and collision cell technology with proprietary ultra-fast technologies. This expands the application range and ensures high-sensitivity, high-throughput analysis at lower levels of detection. It incorporates improved ion optics which integrate two multi-pole RF ion guides, and UFsweeper II collision cell technology to provide higher multiple reaction monitoring (MRM) sensitivity. A five-fold increase in sensitivity (reserpine, S/N ratio) has been achieved by improving ion focusing and minimizing ion losses between multi-pole lenses resulting in higher sensitivity for scan mode measurements, expanding the potential range of LC/MS/MS applications. This unit achieves MRM transition speeds up to 555 MRMs per second. LabSolutions LCMS software offers a variety of data processing features, including a Quantitation Browser, which processes multiple analytes, and a Data Browser, which allows users to analyze and compare multiple sets of data in the same window. Users also can easily optimize MRM parameters with LabSolutions software by utilizing automated flow injection analysis. Shimadzu Scientific Instruments Inc.