Suitable to generate highly innovative ideas for lead molecules in new areas of chemical space, the sparkV10 helps researchers overcome the ‘chemotype trap’. This software will give companies improved IP positions by patent-busting or patent-expansion as well as benefiting from lower-risk and lower-cost strategies for the discovery of new chemical entities. By exploring bioisosteric replacements and using field-similar rather than structure-similar molecules, it will generate new leads, even in crowded therapeutic areas.