Epigenetics is a fast-growing research area with wide applications, including disease mechanism profiling and personalized medicine strategies. Chromatin immunoprecipitation (ChIP) is crucial to epigenetic research.
Porvair Sciences, in conjunction with researchers at Swansea University (UK), have written a new technical article in Nature Methods that provides an introduction to Chromatrap 96. This high-throughput ChIP analysis platform is able to profile up to 96 transcription factors and epigenetic modifications simultaneously in less than 1 day. Authors Amy L Beynon, Lesley J Parkes, Matthew L Turner, Steve Knight, Steve Conlan, Lewis Francis and Ben Stocks demonstrate how the solid-state platform enables sensitive, selective and reproducible target amplification with excellent signal-to-noise ratios, even from samples as small as 0.1 µg. Further, the authors show the compatibility of the platform with automated handling allows for simultaneous investigation of parallel epigenetic landscapes, offering unprecedented ChIP assay flexibility and speed. Porvair Sciences
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