Developed in collaboration with the Oxidative Stress Group at theUniversityofLeicester, the COMPAC-50 enables simultaneous electrophoresis of up to 50 Comet assay slides, saving considerable lab space and reducing slide handling time by up to two-thirds when compared to previous standard methods.
The Comet assay assesses DNA damage, both in academic and commercial research labs. It has recently been introduced into standard tests, used for genotoxicity, by the pharmaceutical industry and for the regulation of chemicals within the European Commission’s Registration, Evaluation and Authorisation of Chemicals Programme. However, its sample throughput has traditionally been a limiting factor, typically limited to handling smaller numbers of slides, and a time-consuming procedure due to their individual manipulation.
The COMPAC-50 incorporates a novel methodology by which multiple slides may be simultaneously manipulated, and undergo electrophoresis, in batches of 25 rather than individually. This decreases assay time by 60%, and offers users the benefit of an electrophoresis tank with a substantially smaller footprint, and more uniform orientation of gels during electrophoresis. The new high-throughput Comet Assay device will greatly increase the number of samples that can be analyzed, decrease assay time, reagent requirements and risk of damage/loss of fragile low melting point gels. Cleaver Scientific
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