Delivering a simplified way to enrich target proteins for downstream mass spectrometric analysis, the Mass Spectrometric Immunoassay (MSIA) pipette tips, provide scientists with an easier immunoaffinity approach that yields better and more reproducible quantification results. Suitable for sample preparation and quantification, data analysis, top-down mass spectrometry-based quantitative proteomic workflow, these tips feature a 300 µl pipette tip embedded with a proprietary, highly porous immunoaffinity column that provides increased sensitivity with improved reproducibility and sample throughput.