Generating high-quality chromatin that gives the best possible ChIP signal can be technically demanding. The PureEpi Chromatin Preparation and Optimization Kit from EMD Millipore provides a set of buffers, detailed methods and optimization guidelines specifically designed for generation of sheared chromatin for ChIP applications. The method offered by the kit is reliable, reproducible and allows users to prepare chromatin from either cultured cells or tissues. The kit provides a complete set of materials for up to 12 chromatin preparations. EMD Millipore, a division of Merck KGaA