The maXis line of ultrahigh-resolution quadrupole time-of-flight (UHR-qTOF) mass spectrometers, brings high resolution and mass accuracy to the liquid chromatography, TOF-MS market space. The system is designed to deliver the resolution and mass accuracy high enough to enable analysis such as unambiguous identification of the mono-isotopic mass peak of both the light and heavy chains of monoclonal antibodies. In addition, this level of performance also provides scientists confident detection and identification of modifications hard to detect at the protein level, such as deamidation.
“The maXis II system delivers the fastest time-to-success for life science researchers and across a broad range of applications from the in-depth identification and characterization of biopharmaceuticals and small molecule pharmaceuticals, to bottom-up proteomics and proteoform screening.” said Dr. Bob Galvin, vice president of Bruker’s Biopharmaceutical Business Unit. “Additionally, the system is well suited to research in the metabolomics, food safety, and forensic and toxicology screening markets as well.”
The system allows the simultaneous analysis of small molecules and megadalton proteins on one analytical platform. It provides >80,000 full-sensitivity resolution (FSR) at UPLC acquisition speeds, a high mass option (HMO) that yields native spray MS capabilities provides enhanced analytical performance levels, and an electron transfer dissociation (ETD) option that provides a powerful additional MS/MS fragmentation technique for the sequence analysis of intact proteins including monoclonal antibody subunits.
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