New crossflow filter device is designed for use in biotechnology applications, especially for membrane screening and small-volume process development. The single- use Sartocon Slice 50ultrafilter is available as an encapsulated and ready-to-use crossflow module with a filter area of 50 cm2 and a wide variety of molecular weight cutoffs. The cGMP validated self-contained unit eliminates the need for a compression holder and is available in a choice of two polymers: The Hydrosart membrane is a stable polymer suitable for a broad pH range and can be depyrogenated using NaOH at elevated temperatures. It is extremely hydrophilic, making it non-protein-binding and virtually non-fouling, and delivers an exceptional high flux. The polyethersulfone membrane (PESU), which is well established in the biotechnological and pharmaceutical industries, is a stable polymer that is suitable for a broad pH and temperature range.
A major benefit of the new crossflow filter device is its linear scalability, along with identical materials of construction. This eases transfer of process development results to the next scale up level.
The device can be interfaced easily with SSB’s recently launched SARTOFLOW® Smart benchtop crossflow system, as well as with many other laboratory-scale filtration systems. Sartorius Stedim Biotech
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